Sickle Cell Disease in Medicine / Internal Medicine — 19yo Man | Hematology | SMLE Q#18472
SMLE Question #18472
Medicine / Internal Medicine
Hematology
Objective: OBJ-101
Last updated: February 2026
A 19-year-old man presents for evaluation of lifelong intermittent episodes of severe limb and back pain, often after dehydration. He has had one hospitalization for acute chest syndrome. Family history includes a cousin with sickle cell disease. Physical examination is unremarkable between episodes. Which of the following is the best test to confirm the diagnosis of sickle cell disease?
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