2 Days Of Sudden in Medicine / Internal Medicine — 35yo Man | Hematology | SMLE Q#15117

SMLE Question #15117

Medicine / Internal Medicine Hematology

Objective: OBJ-101

Last updated: February 2026
A 35-year-old man presents with 2 days of sudden fatigue, generalized weakness, and jaundice. He reports intermittent, self-resolving mild jaundice for several years. His father underwent splenectomy in his 30s for a hematologic disorder. Examination shows mild scleral icterus without splenomegaly. Abdominal ultrasound shows multiple pigment gallstones and a normal-sized spleen. What is the most likely diagnosis?

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