Newly Diagnosed Bulky Diffuse in Medicine / Internal Medicine — 50yo Man | Hematology | SMLE Q#18359
SMLE Question #18359
Medicine / Internal Medicine
Hematology
Objective: OBJ-IM-HEME-001
Last updated: February 2026
A 50-year-old man with newly diagnosed bulky diffuse large B-cell lymphoma is planned to start his first cycle of R-CHOP chemotherapy. He has high tumour burden and elevated LDH, with no baseline renal impairment. You want to start pharmacologic prophylaxis to reduce the risk of chemotherapy-associated tumour lysis syndrome. Which medication is most appropriate for prophylaxis?
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