Future Transfusions in Medicine / Internal Medicine — 34yo Man | Hematology | SMLE Q#16916
SMLE Question #16916
Medicine / Internal Medicine
Hematology
Objective: OBJ-101
Last updated: February 2026
A 34-year-old man is hospitalized after a motorcycle crash and begins a packed red blood cell transfusion. Within 10 minutes, he develops generalized pruritus, urticaria over the trunk and arms, and facial flushing. He has no wheeze, stridor, dyspnea, or hypotension. Symptoms resolve after stopping the transfusion and giving intravenous antihistamine. He is expected to need further transfusions during this admission. What is the most appropriate strategy to reduce recurrence with future transfusions?
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