2 Days Of Fever in Medicine / Internal Medicine — 23yo Woman | Hematology | SMLE Q#12284
SMLE Question #12284
Medicine / Internal Medicine
Hematology
Objective: OBJ-101
Last updated: February 2026
A 23-year-old woman with homozygous sickle cell disease (HbSS) presents with 2 days of fever, pleuritic right-sided chest pain, and worsening shortness of breath 1 week after a vaso-occlusive pain crisis. Chest X-ray shows a new right lower lobe infiltrate. She is started on broad-spectrum IV antibiotics. Over the next few hours, her oxygen requirement increases and her hemoglobin drops below baseline. In addition to continuing appropriate antibiotics, what is the most appropriate next intervention to improve her outcome?
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