Intermittent Low-grade Fever in Medicine / Internal Medicine — 26yo Man | Hematology | SMLE Q#12147
SMLE Question #12147
Medicine / Internal Medicine
Hematology
Objective: OBJ-101
Last updated: February 2026
A 26-year-old man has 3 months of painless left cervical swelling with intermittent low-grade fever, drenching night sweats, and 5 kg unintentional weight loss. Examination shows multiple firm, rubbery, non-tender cervical lymph nodes. CT of the neck and chest shows cervical and mediastinal lymphadenopathy. Excisional lymph node biopsy shows nodular architecture with scattered large binucleated cells with prominent eosinophilic nucleoli in a mixed inflammatory background; the atypical cells are CD15+ and CD30+. What is the most likely diagnosis?
Continue in practice mode
Sign in and start a focused practice session to view options, submit your answer, and read the full explanation.