Chronic Gastrointestinal Blood Loss in Medicine / Internal Medicine — 54yo Man | Hematology | SMLE Q#11935
SMLE Question #11935
Medicine / Internal Medicine
Hematology
Objective: OBJ-101
Last updated: February 2026
A 54-year-old man with chronic gastrointestinal blood loss and symptomatic anemia starts a packed red blood cell transfusion. Two hours after it begins, he develops fever and acute shortness of breath with tachypnea. Lungs are clear on auscultation. There is no hypotension, back pain, dark urine, wheeze, urticaria, angioedema, or signs of volume overload. What is the most likely transfusion reaction causing these symptoms?
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