Closed Femoral Shaft Fracture in Medicine / Internal Medicine — 28yo Man | Hematology | SMLE Q#11678
SMLE Question #11678
Medicine / Internal Medicine
Hematology
Objective: OBJ-101
Last updated: February 2026
A 28-year-old man with a closed femoral shaft fracture receives packed red blood cell transfusion for acute blood loss. Minutes after starting the second unit, he develops sudden dyspnea and agitation. Examination shows diffuse bilateral crackles with no wheeze, urticaria, or angioedema; the transfusion is stopped. What is the most likely cause of his deterioration?
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