Anhedonia in Medicine / Internal Medicine — 13yo Child | Psychiatry | SMLE Q#1413
SMLE Question #1413
Medicine / Internal Medicine
Psychiatry
Last updated: February 2026
A 13-year-old girl has had persistent low mood for 3 months with anhedonia, insomnia, poor concentration, decreased appetite, depressed affect, and slowed speech. She denies substance use and suicidal ideation. A diagnosis of moderate major depressive disorder is made. Psychotherapy is arranged, and pharmacotherapy is being initiated with careful monitoring for adverse effects. Which antidepressant is the most appropriate first-line choice for this patient?
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