3 Weeks Of Persistent in Medicine / Internal Medicine — 55yo Woman | Psychiatry | SMLE Q#9472
SMLE Question #9472
Medicine / Internal Medicine
Psychiatry
Objective: OBJ-253
Last updated: February 2026
A 55-year-old woman presents with 3 weeks of persistent low mood and loss of interest. She reports poor concentration, early-morning awakening, reduced appetite, fatigue, and excessive guilt and worthlessness. She has recurrent thoughts of ending her life but denies a specific plan or recent attempts. Mental status examination shows tearfulness, depressed affect, and psychomotor slowing. Which neurotransmitter deficiency is most likely contributing to her condition?
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