15-year Chronic Hepatitis B in Medicine / Internal Medicine — 55yo Man | Hepatology | SMLE Q#6147
SMLE Question #6147
Medicine / Internal Medicine
Hepatology
Objective: OBJ-HEP-01
Last updated: February 2026
A 55-year-old man with a 15-year history of chronic hepatitis B attends routine follow-up. He reports mild fatigue only. Examination shows no jaundice or ascites. Screening abdominal ultrasound shows a solitary 3 × 3 cm hepatic nodule in the right lobe with mildly coarse liver echotexture. Which of the following is the most appropriate next step to establish the diagnosis and guide management?
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