Generalized Tonic-clonic Epilepsy Has in Medicine / Internal Medicine — 26yo Woman | Neurology | SMLE Q#573
SMLE Question #573
Medicine / Internal Medicine
Neurology
Last updated: February 2026
A 26-year-old woman with generalized tonic-clonic epilepsy has been taking valproate for 3 years with good seizure control. She attends preconception counselling because she and her partner are planning pregnancy. She takes no other medications and her neurological examination is normal. She asks about potential fetal risks from continuing this medication during pregnancy. Which congenital abnormality is most specifically associated with in utero exposure to valproate?
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