5 Days Of Increased in Medicine / Internal Medicine — Case | Infectious Diseases | SMLE Q#380

SMLE Question #380

Medicine / Internal Medicine Infectious Diseases
Last updated: February 2026
A 22-year-old sexually active woman presents with 5 days of increased vaginal discharge and mild lower abdominal discomfort. She has a new male partner and inconsistent condom use. She denies fever, nausea, and dyspareunia. Pelvic examination shows mucopurulent endocervical discharge and mild cervical friability without uterine or adnexal tenderness. Urine pregnancy test is negative. NAAT from a cervical swab is positive for Chlamydia trachomatis and negative for Neisseria gonorrhoeae. What is the most appropriate first-line pharmacologic treatment?

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