6 Hours Of Fever in Medicine / Internal Medicine — 52yo Man | Infectious Diseases | SMLE Q#18384

SMLE Question #18384

Medicine / Internal Medicine Infectious Diseases

Objective: OBJ-349

Last updated: February 2026
A 52-year-old man on cytotoxic chemotherapy for acute leukemia presents with 6 hours of fever and malaise. He has an indwelling central venous catheter. He denies cough, dysuria, abdominal pain, or diarrhea. Examination shows no localizing source of infection. Blood cultures are obtained. What is the most appropriate initial empiric antibiotic therapy?

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