Probable Alzheimer Disease Has in Medicine / Internal Medicine — 74yo Man | Neurology | SMLE Q#17884
SMLE Question #17884
Medicine / Internal Medicine
Neurology
Objective: OBJ-NEURO-AD-THERAPY-001
Last updated: February 2026
A 74-year-old man with probable Alzheimer disease has progressive memory decline affecting daily activities for 6 months. He has taken donepezil 10 mg daily with good adherence and tolerates it. His Mini-Mental State Examination score decreased from 19 to 12 over 6 months. Brain MRI shows bilateral hippocampal atrophy without acute infarct or mass. He has no hallucinations, depressive symptoms, or focal neurologic deficits. What is the most appropriate next step in pharmacologic management of his cognitive decline?
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