Several Months Of Progressive in Medicine / Internal Medicine — 35yo Man | Hepatology | SMLE Q#16758
SMLE Question #16758
Medicine / Internal Medicine
Hepatology
Objective: OBJ-HEP-01
Last updated: February 2026
A 35-year-old man with a 7-year history of ulcerative colitis presents with several months of progressive fatigue, generalized pruritus, and jaundice. Examination shows scleral icterus and excoriations. Alanine aminotransferase is mildly elevated. MRCP shows multifocal short strictures with intervening dilatation involving both intrahepatic and extrahepatic bile ducts. What is the most likely diagnosis?
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