Newly Diagnosed Acute Myelomonocytic in Medicine / Internal Medicine — 26yo Man | Infectious Diseases | SMLE Q#16480

SMLE Question #16480

Medicine / Internal Medicine Infectious Diseases

Objective: OBJ-349

Last updated: February 2026
A 26-year-old man with newly diagnosed acute myelomonocytic leukemia is admitted for induction chemotherapy and placed in protective isolation. On the day before chemotherapy, he develops fever without focal symptoms. Examination shows no localizing source; lungs are clear and the peripheral cannula site is clean. Blood and urine cultures are obtained. He is hemodynamically stable but has marked neutropenia. What is the most appropriate initial management for his fever?

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