Increased Tone in Medicine / Internal Medicine — Case | Neurology | SMLE Q#12064

SMLE Question #12064

Medicine / Internal Medicine Neurology

Objective: OBJ-307

Last updated: February 2026
A 10-month-old boy is evaluated for delayed gross motor development. He required neonatal intensive care for several weeks after birth. When supported upright, he has scissoring of the legs with increased tone. Deep tendon reflexes in both legs are brisk with sustained ankle clonus. Brain MRI shows periventricular leukomalacia. Which of the following is most strongly associated with this diagnosis?

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