Same Susceptibility Profile in Medicine / Internal Medicine — 48yo Woman | Infectious Diseases | SMLE Q#11795
SMLE Question #11795
Medicine / Internal Medicine
Infectious Diseases
Objective: OBJ-349
Last updated: February 2026
A 48-year-old woman is hospitalized for acute pyelonephritis. She has received IV ceftriaxone for 5 days after urine culture grew Escherichia coli susceptible to ceftriaxone. Over the last 48 hours, she has persistent fever and worsening left flank pain after slight initial improvement. Examination shows marked left costovertebral angle tenderness. A repeat urine culture again grows E coli with the same susceptibility profile, and blood cultures are pending. What is the most appropriate next step in management?
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