9-year-old Boy in Pediatrics — 9yo Child | Pediatric Infectious | SMLE Q#758

SMLE Question #758

Pediatrics Pediatric Infectious

Objective: OBJ-113

Last updated: February 2026
A 9-year-old boy has 5 days of sore throat, low-grade fever, and fatigue. He started oral amoxicillin 2 days ago. He now has a diffuse, nonpruritic erythematous maculopapular rash on the trunk and extremities without urticaria or mucosal involvement. Examination shows enlarged exudative tonsils, posterior cervical lymphadenopathy, and mild splenomegaly. A rapid streptococcal antigen test done before antibiotics was negative. What is the most likely underlying diagnosis?

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