Sun Exposure in Medicine / Internal Medicine — 26yo Woman | Rheumatology | SMLE Q#5641
SMLE Question #5641
Medicine / Internal Medicine
Rheumatology
Objective: OBJ-383
Last updated: February 2026
A 26-year-old woman has 3 months of fatigue, low-grade fevers, intermittent pain in her hands and knees, and a facial rash that worsens with sun exposure. Examination shows a malar rash sparing the nasolabial folds and mild tenderness of the small joints of both hands without deformity. Initial testing shows normocytic anemia and a positive ANA. Further serology is requested to help confirm suspected systemic lupus erythematosus. Which of the following tests is most specific for SLE?
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