28-year-old Woman in Medicine / Internal Medicine — 28yo Woman | Rheumatology | SMLE Q#399
SMLE Question #399
Medicine / Internal Medicine
Rheumatology
Last updated: February 2026
A 28-year-old woman has had three consecutive spontaneous abortions at 9–11 weeks over 3 years and has no living children. Between pregnancies, she has had two episodes of left-leg deep vein thrombosis, including one 6 months ago while not pregnant and not using hormonal contraception. Prior evaluations showed normal parental karyotypes and no uterine anomalies on pelvic ultrasound. A thrombophilia workup is being repeated, including lupus anticoagulant and anticardiolipin antibodies. What is the most likely underlying diagnosis?
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