Low Estradiol in Obstetrics & Gynecology — 15yo Child | General Gynecology | SMLE Q#19931
SMLE Question #19931
Obstetrics & Gynecology
General Gynecology
Objective: OBJ-ETH-STERIL
Last updated: May 2026
A 15-year-old girl is evaluated for primary amenorrhea. She has no breast development, scant pubic hair, short stature, a broad chest, and widely spaced nipples. She is not sexually active and takes no medications. Pelvic ultrasound shows a small uterus and streak gonads. Testing shows elevated gonadotropins with low estradiol and a 45,X karyotype. What is the most appropriate management to induce puberty and protect long-term bone and cardiovascular health?
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