38-year-old Woman in Medicine / Internal Medicine — 38yo Woman | Endocrinology | SMLE Q#18699
SMLE Question #18699
Medicine / Internal Medicine
Endocrinology
Objective: OBJ-ADDISON-DOSE-1
Last updated: February 2026
A 38-year-old woman has 8 months of progressive weight gain, proximal muscle weakness, easy bruising, and new hypertension. Examination shows facial plethora, dorsocervical fat pad, central obesity, and wide violaceous abdominal striae. An 08:00 serum cortisol and plasma ACTH are obtained as part of the evaluation. Which of the following is the most likely diagnosis?
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