Sustained Handgrip in Medicine / Internal Medicine — Case | Cardiology | SMLE Q#18543
SMLE Question #18543
Medicine / Internal Medicine
Cardiology
Objective: OBJ-163
Last updated: February 2026
A 24-year-old patient is evaluated for intermittent palpitations and brief, atypical left-sided chest discomfort. Cardiac auscultation reveals a midsystolic click followed by a late systolic murmur best heard at the apex. The murmur becomes louder when standing from a squatting position and becomes softer with sustained handgrip. Which of the following is the most likely diagnosis?
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