1 Day Of Severe in Medicine / Internal Medicine — 24yo Woman | Rheumatology | SMLE Q#18126

SMLE Question #18126

Medicine / Internal Medicine Rheumatology

Objective: OBJ-NEUROLUPUS-001

Last updated: February 2026
A 24-year-old woman with known systemic lupus erythematosus presents with 1 day of severe headache, confusion, and a new generalized tonic-clonic seizure. Neurologic examination shows disorientation without focal deficits. CT brain shows no hemorrhage or mass lesion. Lumbar puncture is unremarkable and initial infectious studies are negative. She is started on high-dose IV methylprednisolone. Which additional medication should be given to induce remission?

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