Large-volume Hematemesis in Medicine / Internal Medicine — 46yo Man | Gastroenterology | SMLE Q#17637
SMLE Question #17637
Medicine / Internal Medicine
Gastroenterology
Objective: OBJ-IM-GI-UGIB-001
Last updated: February 2026
A 46-year-old man presents to the emergency department with large-volume hematemesis. He reports several weeks of epigastric pain that improves with meals and takes ibuprofen daily for back pain. He has no history of alcohol use disorder, known liver disease, or prior retching. Examination shows epigastric tenderness without jaundice, ascites, or spider naevi. What is the most likely cause of his bleeding?
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