6 Weeks Of Burning in Medicine / Internal Medicine — 45yo Woman | Gastroenterology | SMLE Q#17439
SMLE Question #17439
Medicine / Internal Medicine
Gastroenterology
Objective: OBJ-IM-GI-ULCER-NSAID-001
Last updated: February 2026
A 45-year-old woman presents with 6 weeks of burning epigastric pain that occurs at night and improves briefly with food. She has been taking ibuprofen 800 mg three times daily for chronic knee osteoarthritis. She denies weight loss, vomiting, melena, hematemesis, or dysphagia. Upper endoscopy shows a single 1-cm duodenal ulcer with a clean base and no active bleeding. Gastric and duodenal biopsies are negative for Helicobacter pylori. What is the most appropriate next step in management?
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