Multiple Chronic Diseases in Patient Safety, Preventive & Ethics — Case | Epidemiology & Biostatistics | SMLE Q#17085
SMLE Question #17085
Patient Safety, Preventive & Ethics
Epidemiology & Biostatistics
Objective: OBJ-367
Last updated: February 2026
A randomized controlled trial at a single tertiary cancer centre evaluates a new chemotherapy for advanced solid tumours. Eligibility excluded significant cardiovascular, renal, or hepatic comorbidity. Most participants were aged 30–49 years. The intervention group had a 15% absolute improvement in 5-year survival versus standard therapy. Investigators wish to apply the results to the national cancer population, including older adults with multiple chronic diseases. Which study feature most limits external validity?
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