3 Years Of Heartburn in Medicine / Internal Medicine — 55yo Man | Gastroenterology | SMLE Q#16928

SMLE Question #16928

Medicine / Internal Medicine Gastroenterology

Objective: OBJ-433

Last updated: February 2026
A 55-year-old man presents to a gastroenterology clinic with 3 years of heartburn and regurgitation partially relieved by proton pump inhibitors. He has no dysphagia, odynophagia, or weight loss. Upper endoscopy shows salmon-colored, velvety mucosa extending 3 cm above the gastroesophageal junction in the distal esophagus. Biopsies from this segment show intestinal metaplasia with goblet cells. What is the most likely diagnosis?

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