45-year-old Man in Medicine / Internal Medicine — 45yo Man | Endocrinology | SMLE Q#16843
SMLE Question #16843
Medicine / Internal Medicine
Endocrinology
Objective: OBJ-ADDISON-DOSE-1
Last updated: February 2026
A 45-year-old man has 6 months of watery diarrhea, epigastric pain, and 8-kg weight loss. Upper endoscopy on two occasions shows multiple duodenal ulcers despite high-dose proton pump inhibitor therapy. He has not used NSAIDs, and Helicobacter pylori testing is negative. What is the most likely diagnosis?
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