6 Months Of Progressive in Medicine / Internal Medicine — 42yo Woman | Endocrinology | SMLE Q#16644
SMLE Question #16644
Medicine / Internal Medicine
Endocrinology
Objective: OBJ-ADDISON-DOSE-1
Last updated: February 2026
A 42-year-old woman presents with 6 months of progressive fatigue, cold intolerance, constipation, dry skin, and a 7-kg weight gain despite no dietary change. She reports slowed thinking. Examination shows periorbital puffiness, coarse dry skin, and a mildly enlarged, non-tender thyroid gland. Thyroid function tests are shown below. Which of the following is the most likely diagnosis?
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