10-year Gastroesophageal Reflux Disease in Medicine / Internal Medicine — 55yo Man | Gastroenterology | SMLE Q#1395
SMLE Question #1395
Medicine / Internal Medicine
Gastroenterology
Last updated: February 2026
A 55-year-old man with a 10-year history of gastroesophageal reflux disease presents for routine follow-up. He reports intermittent heartburn and occasional progressive dysphagia to solids. He does not smoke or drink alcohol, and there is no family history of esophageal cancer. Upper gastrointestinal endoscopy 1 year ago showed reflux esophagitis without stricture or mass, and esophageal biopsies showed no dysplasia. In patients with long-standing reflux disease, which factor most strongly increases the risk of developing esophageal adenocarcinoma?
Continue in practice mode
Sign in and start a focused practice session to view options, submit your answer, and read the full explanation.