2 Months Of Polyuria in Medicine / Internal Medicine — 50yo Woman | Endocrinology | SMLE Q#12322
SMLE Question #12322
Medicine / Internal Medicine
Endocrinology
Objective: OBJ-ADDISON-DOSE-1
Last updated: February 2026
A 50-year-old woman with metastatic breast cancer on chemotherapy presents with 2 months of polyuria, intense thirst, and nocturia. She takes an SSRI. She does not use diuretics or lithium and has had no recent head trauma. Examination shows mildly dry mucous membranes. Random plasma glucose is normal. Laboratory testing shows hypernatremia with very dilute urine. What is the most likely diagnosis?
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