Rheumatoid Arthritis On Hydroxychloroquine in Medicine / Internal Medicine — 35yo Woman | Nephrology | SMLE Q#12143
SMLE Question #12143
Medicine / Internal Medicine
Nephrology
Objective: OBJ-188
Last updated: February 2026
A 35-year-old woman with rheumatoid arthritis on hydroxychloroquine is admitted for community-acquired pneumonia and started on intravenous cefuroxime with clinical improvement. Baseline renal function was normal. On day 5 of antibiotic therapy, she develops an acute rise in serum creatinine and urea. Urinalysis shows mild proteinuria, leukocyturia, and occasional eosinophils, without hematuria or casts. She has had no episodes of hypotension or clinical volume depletion. Which of the following is the most likely cause of her kidney function deterioration?
Continue in practice mode
Sign in and start a focused practice session to view options, submit your answer, and read the full explanation.