4-kg Weight Gain Despite in Medicine / Internal Medicine — 35yo Woman | Endocrinology | SMLE Q#11994
SMLE Question #11994
Medicine / Internal Medicine
Endocrinology
Objective: OBJ-ADDISON-DOSE-1
Last updated: February 2026
A 35-year-old woman has 3 months of progressive fatigue and lethargy with 4-kg weight gain despite no change in diet or activity. She reports cold intolerance and mild constipation. She takes no medications and has no significant past medical history. Examination shows no goiter and no eye signs. What is the most appropriate initial investigation?
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