Sickle Cell Disease Develops in Pediatrics — 5yo Child | Pediatric Heme/Onc | SMLE Q#11527

SMLE Question #11527

Pediatrics Pediatric Heme/Onc

Objective: OBJ-153

Last updated: February 2026
A 5-year-old boy with sickle cell disease develops sudden severe pain in both hands and feet for 6 hours, not relieved by paracetamol. He has decreased oral intake. Exam shows painful swelling of the hands and feet. He has no cough, dyspnoea, or chest pain, and his spleen is not palpable. What is the most likely cause of this presentation?

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