Multiple Palpable Nodules in Medicine / Internal Medicine — 56yo Woman | Endocrinology | SMLE Q#11517

SMLE Question #11517

Medicine / Internal Medicine Endocrinology

Objective: OBJ-ADDISON-DOSE-1

Last updated: February 2026
A 56-year-old woman has 3 months of unintentional 6-kg weight loss despite increased appetite, heat intolerance, palpitations, and insomnia. Examination shows fine tremor, warm moist skin, and a non-tender, irregularly enlarged thyroid with multiple palpable nodules and no bruit; there is no ophthalmopathy or dermopathy. Thyroid receptor antibodies are negative, and a radioactive iodine uptake scan is ordered to help determine the cause. Which of the following is the most likely diagnosis?

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