Known Crohn Disease Has in Medicine / Internal Medicine — 28yo Man | Gastroenterology | SMLE Q#11513
SMLE Question #11513
Medicine / Internal Medicine
Gastroenterology
Objective: OBJ-433
Last updated: February 2026
A 28-year-old man with known Crohn disease has 3 weeks of worsening symptoms with 8–10 stools/day, bloody diarrhea, crampy abdominal pain, nocturnal symptoms, and 5-kg unintentional weight loss. He has taken oral prednisone 50 mg daily for 6 weeks with minimal improvement. He previously did not respond to mesalamine and is taking azathioprine for maintenance. Infectious stool studies are negative. What is the most appropriate next step in management?
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