Elevated Transaminases in Pediatrics — Case | Pediatric Infectious | SMLE Q#11448

SMLE Question #11448

Pediatrics Pediatric Infectious

Objective: OBJ-113

Last updated: February 2026
A 2-day-old male newborn has poor feeding and lethargy. Examination shows microcephaly, abdominal distension, and hepatosplenomegaly. Initial blood tests show pancytopenia with elevated transaminases. The neonatology team is evaluating the underlying etiology of these findings. What is the most appropriate next diagnostic step?

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