Clarithromycin in Medicine / Internal Medicine — 32yo Woman | Gastroenterology | SMLE Q#11387
SMLE Question #11387
Medicine / Internal Medicine
Gastroenterology
Objective: OBJ-433
Last updated: February 2026
A 32-year-old woman is receiving treatment for Helicobacter pylori–associated peptic ulcer disease with clarithromycin, amoxicillin, and a proton pump inhibitor, plus an over-the-counter medication for dyspepsia. After several days, she notices her stool has become very dark. She has no abdominal pain, vomiting, dizziness, weakness, or overt rectal bleeding. She is otherwise well and asks about a harmless medication side effect. Which medication is most likely responsible for this benign stool discoloration?
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