Nocturnal Regurgitation Of Undigested in Medicine / Internal Medicine — 45yo Man | Gastroenterology | SMLE Q#11370

SMLE Question #11370

Medicine / Internal Medicine Gastroenterology

Objective: OBJ-433

Last updated: February 2026
A 45-year-old man has 1 year of progressive dysphagia to solids and liquids with nocturnal regurgitation of undigested food and intermittent retrosternal discomfort. He has no history of caustic ingestion and has mild weight loss. Physical examination is unremarkable. A prior barium swallow showed a dilated esophagus with smooth tapering at the gastroesophageal junction. What is the best diagnostic test to confirm the diagnosis?

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