Only Mild Improvement in Medicine / Internal Medicine — 32yo Man | Gastroenterology | SMLE Q#11206

SMLE Question #11206

Medicine / Internal Medicine Gastroenterology

Objective: OBJ-433

Last updated: February 2026
A 32-year-old man has 3 years of heartburn and regurgitation, worse after large meals and when lying flat. He reports good adherence to a twice-daily proton pump inhibitor taken before meals for 8 weeks, with only mild improvement. Upper endoscopy last week was normal, with no esophagitis or Barrett esophagus. His physician wants objective evidence of reflux before considering invasive therapy or alternative diagnoses. What is the most appropriate next step in management?

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