Several Episodes Of Fresh in Medicine / Internal Medicine — 46yo Man | Gastroenterology | SMLE Q#11090

SMLE Question #11090

Medicine / Internal Medicine Gastroenterology

Objective: OBJ-433

Last updated: February 2026
A 46-year-old man presents to the emergency department with several episodes of fresh hematemesis over 6 hours. He has nausea but no preceding severe retching or prolonged vomiting. He denies alcohol use disorder, NSAID use, anticoagulant therapy, prior gastrointestinal bleeding, or known liver disease. Physical examination shows no stigmata of chronic liver disease. Upper endoscopy is planned after initial stabilization. What is the most likely cause of his upper gastrointestinal bleeding?

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