1-year Systemic Lupus Erythematosus in Medicine / Internal Medicine — 27yo Woman | Rheumatology | SMLE Q#11062

SMLE Question #11062

Medicine / Internal Medicine Rheumatology

Objective: OBJ-383

Last updated: February 2026
A 27-year-old woman with a 1-year history of systemic lupus erythematosus is seen in clinic for follow-up. She has fatigue and persistent inflammatory arthralgias despite hydroxychloroquine, intermittent NSAIDs, and low-dose prednisone. She has no clinical evidence of renal, neurologic, cardiopulmonary, or hematologic organ-threatening disease. Urinalysis is unremarkable. Which of the following is the most appropriate treatment option at this time?

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