2 Weeks Of Crampy in Medicine / Internal Medicine — 28yo Woman | Gastroenterology | SMLE Q#3586

SMLE Question #3586

Medicine / Internal Medicine Gastroenterology
Last updated: January 2026
A 28-year-old woman presents with 2 weeks of crampy lower abdominal pain, bloody diarrhea, and tenesmus. She reports low-grade fever and weight loss over the past month. Physical examination shows mild diffuse lower abdominal tenderness without peritoneal signs. Vital signs: T: 38.5 °C, BP: 110/70 mmHg, HR: 98/min, RR: 18/min, SpO2: 98% on room air. Lab results: hemoglobin 9.8 g/dL, CRP 1.5 mg/dL (elevated), urea 60 mg/dL (elevated), WBC 11,500/µL. Colonoscopy demonstrates continuous mucosal inflammation starting from the rectum and extending proximally through the colon without skip lesions. Which is the most likely diagnosis?

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